When something hurts the first thing to do is typically to put ice on it for 15-20 minutes and follow general RICE instructions: Rest, Ice Compression and Elevation for several days. But what happens if that body part is still visibly swollen and or painful after a few days. At this time many turn to ibuprofen, Advil or something stronger. Unfortunately, these often come with unwanted short and or long term side effects.
Avoid gastric upset and the risk of GI bleeding that comes with Aspirin, Naprosyn and even some NSAIDS like ibuprofen and Advil. Proteolytic enzymes won’t affect your kidneys like medications do. THESE ARE GREAT FOR ATHLETES AND CHILDREN WHO NEED HELP REDUCING INFLAMMATION, RECOVERING FROM INJURY OR PHYSICAL STRESS. In addition, enzymes have been shown to improve cardiovascular and immune health.
How Do Enzymes Work?
Enzymes are complex proteins that catalyze metabolic reactions throughout the body, and sufficient levels are required for optimizing many of the body’s functions. Although the body produces its own supply of enzymes, the amount produced can vary from person to person and is affected by age, diet, biochemistry and stress. Enzymes fall into three broad categories: metabolic enzymes, manufactured by cells to carry out various functions; digestive enzymes, primarily manufactured by the pancreas to digest foods and absorb nutrients and food enzymes; and exogenous (from outside the body) enzymes from plants and animals, also necessary for aiding and accelerating digestion. Vascuzyme supports the breakdown of unneeded proteins, which research has shown to be an important component of cardiovascular health and supporting optimal blood vessel function. In cases of soft tissue discomfort and exercise recovery, Vascuzyme helps to break down fibrin to support areas of inflammation and reduce recovery times. Research has shown that proteolytic enzymes are well-absorbed from the gastrointestinal tract (GI) tract into the systemic circulation. [1,2]
Studies have highlighted the efficacy of systemic enzyme therapy for a variety of uses, including supporting a normal inflammatory response, nasal passage health, bronchial health, [3,4] musculoskeletal health and exercise-related recovery. [5-8] In vitro, animal and human data show that enzyme therapies are capable of cleaving immune complexes, which are known inflammatory mediators. [9,10] In one study, among four different types of immune complexes prepared in vitro and incubated with different concentrations of an enzyme mixture (papain or pancreatin) approximately 90% of the antigen complexes were cleaved by low doses of enzymes. In addition, antibody complexes were gradually cleaved by concentrations from 5-80 mg.  Proteolytic enzymes have also been shown to reduce levels of the immune marker, TGF-β (Transforming Growth Factor- beta), by converting the protease inhibitor alpha2M from the slow form into the fast form, which binds and inactivates TGF-β. In one study, oral proteolytic enzyme therapy reduced TGF-β levels, supporting the normal inflammatory process.  A study done in children who were given either a polyenzyme mixture or a monoenzyme agent, found that those receiving the polyenzyme mix maintained optimal balance of pro- inflammatory cytokines (IL-2, IL-6, and TNF-α). The anti- inflammatory cytokine IL-4 demonstrated the potency of polyenzyme therapy to support a healthy cycle of inflammation and promote tissue recovery.  Enzyme therapy has also been shown to reduce swelling.  In addition, enzyme therapy supports improvements in discomfort, stiffness and mobility among those with musculoskeletal challenges. 
Researchers also found significant improvements among 103 patients, with knee discomfort given enzyme therapy.
Research has also shown that flavonoids, such as rutin and quercetin, support a normal inflammatory response.
Specifically, they have been shown to reduce the production of TNF-α by macrophages, microglial cells and mast cells helping to maintain a healthy cycle of inflammation.  In a randomized, single-blind study on the antioxidant effect of rutin, after six weeks, those receiving rutin had significantly elevated plasma flavonoids (quercetin, kaempferol and isorhamnetin) displaying the powerful antioxidant effect of rutin.  Quercetin was also found to decrease the expression and production of TNF-α, IL-1beta, IL-6, and Il-8.  Finally, systemic enzyme therapy has been shown to stimulate internal defenses to support a normal musculoskeletal inflammatory response. Systemic enzyme therapy has been shown to modulate cytokine levels and shift “immune balance” away from immune hyperactivity and create a calm, efficient immune state.
Physicians Preferred Brand has a formula that contains some of my favorite blends and amounts of enzymes and herbs for reducing inflammation. Inflamazyme helps support normal blood circulation, vessel function and a normal inflammatory response. It also promotes recovery from exercise and physical stress. By supporting the breakdown of unwanted proteins generated during injury and tissue damage for a normal recovery process, Inflamazyme has applications for a broad range of health needs. Inflamazyme’s enzyme blend includes protease, amylase, papain, trypsin, lipase, chymotrypsin and bromelain, along with quercetin and rutin, two well-known flavonoids. It is formulated with a unique delayed-release delivery system to ensure the enzymes are released intact in the small intestine.
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2. Liebow C, Rothman SS. Enteropancreatic Circulation of
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3. Taussig SJ, Yokoyama MM, Chinen A, Onari K, Yamakido
M. Bromelain: a proteolytic enzyme and its clinical
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Hiroshima J Med Sci
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Eye Ear Nose Throat Mon.
5. Trickett P. Proteolytic enzymes in treatment of athletic
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contraction-induced skeletal muscle injury by bromelain.
Med Sci Sports Exerc
. 1992 Jan;24(1):20-5.
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reduces mild acute knee pain and improves well-being in
a dose-dependent fashion in an open study of otherwise
8. Brien S, Lewith G, Walker A, Hicks SM, Middleton D.
Bromelain as a Treatment for Osteoarthritis: a Review of
Clinical Studies. Evidence-based Complementary and
9. Steffen, C. and Menzel, J. [Basic studies on enzyme
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10. Steffen, C.; Smolen, J. et al. [Enzyme therapy in
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12. Desser, L.; Holomanova, D. et al. Oral therapy with
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13. Minaev, S.V.; Nemilova, T.K.; and Knorring, G.I.
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15. Klein, G.; Kullich, W. et al. Efficacy and tolerance of an
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16. Kumazawa, Y.; Kawaguchi, K.; and Takimoto, H.
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